Alzheimer’s Disease


Alzheimer’s is a degenerative brain disease and the most common cause of dementia. It affects memory, thinking, and behavior.

Read more below about how stem cell research is helping in the fight against Alzheimer’s.

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How Stem Cells Can be Used to Model and Treat Alzheimer’s Disease

  • Using cells from Alzheimer’s patients, researchers can model the disease in a dish and test potential medications on those cells to identify “hits”. These “models in-a-dish” are called organoids and have become a very powerful tool for the study of disease mechanisms.
  • Notably, Prop 14 dedicates $1.5 billion to the study of diseases related to the central nervous system, which includes Alzheimer’s disease.

CIRM’s Progress: Selected Research Highlights

  • Researchers at UCSD are investigating viable candidate drugs to reduce Alzheimer’s disease (AD) pathologies. In short, using reprogrammed stem cells (human induced Pluripotent Stem Cells or hiPSC) from patients that have rare and aggressive hereditary forms of AD, these scientists have modeled AD in the dish to: 1) understand the mechanisms that cause the disease, and 2) screen either FDA-approved drugs to potentially re-purpose them or identify novel therapies for treatment of the disease.

Alzheimer’s Disease Organizations Endorsing YES on Prop 14

 

To see the full list of over 80 patient advocate organizations that endorse YES on Prop 14, please click here.